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Within a the latest study, we claimed the identification as well as the characterization of a completely new atypical opioid receptor with special damaging regulatory Qualities to opioid peptides.1 Our success showed that ACKR3/CXCR7, hitherto generally known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a wide-spectrum